Does memantine affect dopamine?

Does memantine affect dopamine?

Memantine (5, 10 and 20 mg/kg i.p.) caused a dose-dependent increase in dopamine release up to nearly 50% over basal levels. The output of the metabolites was of later onset and longer duration in prefrontal cortex and in striatum.

Is memantine a dopamine antagonist?

Memantine is an uncompetitive and low‐affinity NMDA receptor antagonist with voltage‐dependent binding (Bormann, 1989). Unlike amantadine, memantine has no dopaminergic or anticholinergic actions.

What is memantine mechanism of action?

Memantine is a clinically useful drug in many neurological disorders, including Alzheimer’s disease. The principal mechanism of action of memantine is believed to be the blockade of current flow through channels of N-methyl-d-aspartate (NMDA) receptors–a glutamate receptor subfamily broadly involved in brain function.

What does memantine do to glutamate?

When too much glutamate is present it sticks to the receptors, allowing too much calcium to move into the brain cells causing damage. Memantine sticks to the same receptors, blocking glutamate, and this prevents too much calcium from moving into the brain cells.

Is memantine a dopamine agonist?

Memantine acts as an agonist at the dopamine D2 receptor with equal or slightly higher affinity than to the NMDA receptors.

Is memantine a stimulant?

Memantine acts as a cholinergic stimulant in the mouse hippocampus.

What are the contraindications of memantine?

Contraindications / Precautions

• General Information.
• Renal failure, renal impairment, renal tubular acidosis (RTA), urinary tract infection (UTI)
• Hepatic disease.
• Geriatric.
• Pregnancy.
• Breast-feeding.
• Children, infants.

Is memantine a NMDA receptor agonist?

Memantine is a moderate affinity, uncompetitive NMDA receptor antagonist with strong voltage-dependency and fast kinetics.

What are the effects of memantine?

Memantine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• dizziness.
• confusion.
• aggression.
• depression.
• headache.
• sleepiness.
• diarrhea.
• constipation.

Does memantine help with anxiety?

Memantine augmentation resulted in clinically relevant reduction in anxiety symptoms when compared to baseline. Forty percent of patients achieved remission (HAM-A ≥ 7).

What are side effects of memantine?

SIDE EFFECTS: Body aches, dizziness, constipation, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.