What is the site of action of aldosterone?

What is the site of action of aldosterone?

Abstract. Aldosterone is a type of steroid hormone that acts primarily in renal collecting ducts to stimulate reabsorption of Na+ as well as secretion of K+ and H+. It binds with intracellular receptors in the nucleus that stimulate the expression of several genes.

How is aldosterone synthesized?

Aldosterone is synthesized in the body from corticosterone, a steroid derived from cholesterol. Production of aldosterone (in adult humans, about 20–200 micrograms per day) in the zona glomerulosa of the adrenal cortex is regulated by the renin-angiotensin system.

Does the kidney synthesize aldosterone?

Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon….Aldosterone.

What does the zona glomerulosa do?

1. Zona glomerulosa, the outermost zone of the adrenal cortex secretes mineralcorticoids. These hormones are important for fluid homeostasis. These include aldosterone, which regulates absorption/uptake of K+ and Na+ levels in the kidney.

Where are aldosterone receptors located?

We conclude that aldosterone receptor sites exist on the cell surface of vascular endothelial cells distinct from the classical mineralocorticoid receptors and insensitive to glucocorticoids.

What is the action of the hormone aldosterone quizlet?

What is the function of aldosterone in the body? Aldosterone promotes reabsorption of sodium and water into the body, which helps in maintaining blood pressure.

Where is the main site of aldosterone synthesis quizlet?

Where is the main site of aldosterone synthesis? The adrenal cortex, not the liver, kidneys, or the hypothalamus, synthesizes aldosterone. A patient with one kidney underwent surgery for an adrenal tumor that removed a large portion of the zona glomerulosa.

Where is aldosterone produced Zona?

zona glomerulosa
Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium homeostasis, thereby helping to control blood volume and blood pressure.

What are adrenals?

Adrenal glands, also known as suprarenal glands, are small, triangular-shaped glands located on top of both kidneys. Adrenal glands produce hormones that help regulate your metabolism, immune system, blood pressure, response to stress and other essential functions.

What type of receptor is the aldosterone receptor?

The aldosterone receptor, also referred to as the mineralocorticoid receptor (MR), is a member of the nuclear receptor superfamily (NR3C2) that acts as a ligand-dependent transcription factor mediating mineralocorticoid effects on a large variety of target cells.

What receptor does aldosterone bind to?

Aldosterone and Mineralocorticoid Receptors The mineralocorticoid receptor binds both aldosterone and cortisol with equal affinity.