How many CNVs are there?

How many CNVs are there?

How many CNVs are there?

How many CNVs are there in the human genome and how big are they? To date, approximately 2000 CNVs have been described and 1447 of them are from the current study. There could be thousands more CNVs in the human population.

Is schizophrenia a Mendelian disorder?

(i) No Mendelian variants for schizophrenia are known. A Mendelian form of schizophrenia would be expected to be rare with a very high genotypic relative risk (>50).

Do copy number variants play a role in genetic risk for schizophrenia?

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes.

How common are copy number variants?

The first category includes copy number polymorphisms (CNPs), which are common in the general population, occurring with an overall frequency of greater than 1%.

What neurotransmitters cause schizophrenia?

Research suggests schizophrenia may be caused by a change in the level of 2 neurotransmitters: dopamine and serotonin. Some studies indicate an imbalance between the 2 may be the basis of the problem. Others have found a change in the body’s sensitivity to the neurotransmitters is part of the cause of schizophrenia.

What is the role of myelin in the possible development of schizophrenia?

Post-mortem examination of schizophrenic brains has demonstrated structural abnormalities in both myelin sheaths and oligodendroglia and it has been hypothesized that oligodendroglial dysfunction induces abnormalities in myelin, thereby contributing to the disease etiology.

What are copy number variants in schizophrenia?

Genomic copy number variations (CNVs) are one of the main forms of genomic variations, ubiquitously occurring in the human genome. An increasing number of studies have shown that CNVs account for population diversity and genetically related diseases, including schizophrenia.